Staff Scientist II - Molecular Biology

Job Requisition #: JR55518

End Date: 4/30/2021

Location: Newark, Delaware

Position Type: Professional

Shift: Day Shift, No Rotation

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Staff Scientist II will utilize their Molecular Biology experience and knowledge to work with a cross-functional team of cell and molecular biologists within the Gene Editing Institute. The successful candidate is expected to carry out the assigned projects mostly independently. Primary responsibilities include but are not limited to developing, optimizing, executing and analyzing in-silico, in-vitro and in-vivo CRISPR off-target assays for gene therapy products.


Design and optimize PCR reactions

Restriction digestion, conventional and seamless cloning

Perform total RNA and genomic DNA purification from mammalian cells

Carry out Sanger and next generation sequencing (NGS)

Perform transfection and/or transduction of mammalian cells utilizing nucleofection and/or AAV

Interpretation of Sanger and NGS data

Close communication with all involved team members and supervisors

Maintenance of laboratory equipment

Maintenance of a highly organized, technical and detailed laboratory notebook containing protocols used, results derived from each experiment or measurement

Preparation and dissemination of technical reports

Present research findings, including preparation of research reports and abstracts, dissemination at national and international scientific conferences and publication of manuscripts by peer-reviewed scientific journals.  

Maintain familiarity with current scientific literature and techniques in the field of CRISPR based gene therapy

Perform assigned work safely, adhering to established departmental safety rules and practices; report to Group leader, in a timely manner, any unsafe activities, conditions, hazards, or safety violations that may cause injury to oneself, other employees, patients and visitors.

Performs other related duties as required/assigned.


Scientific opinions and discussion to collaborators. 


Limited supervision of laboratory assistants


Group leader / Director of Gene Editing Institute


Bachelor's degree in molecular biology, biochemistry, biological sciences or related field with 3 - 7 years of work experience or MS with 0 - 4 years of work experience

Extensive experience with wide variety of molecular biology techniques

Experience with Sanger and Next-generation sequencing and analysis is a plus

Experience in fast-paced biotechnology industry is preferred

Experience in cell and molecular biology assay development

Experience with managing multiple projects simultaneously


Strong knowledge and skill base of molecular biology methods

Well-versed in culturing mammalian cells is a plus

Strong troubleshooting skills

Adaptable to incorporating new methods to improve various aspects of workflows

Ability to effectively work independently and as part of a team

Skilled in effective communication and reporting with team members and supervisors

Knowledge in CRISPR genome engineering

Experienced in in vitro assays using immortalized cancer cells

Experienced in cancer biology/genetics




Frequent sitting, standing and walking with or without reasonable accommodation for physical disabilities


Office, clinical and laboratory settings

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For the Love of Health.

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At ChristianaCare, we’re committed to treating everyone with dignity and respect. We believe in a safe, inclusive work environment that fosters collaboration between caregivers from all walks of life. We know that each unique viewpoint is vital in delivering high-quality, safe patient care to everyone who walks through our doors. Our policies, benefits, hiring practices, employee resource groups, and corporate citizenship demonstrate our commitment to inclusion and diversity throughout our system.

Why do we embrace inclusion and diversity? For the Love of Health.

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We serve together in Love and Excellence. Our unique values, Love and Excellence are bold and powerful, and they are the reason why working for ChristianaCare is special. The behaviors associated with our values guide how caregivers interact with everyone they work with and make for an exceptional work experience. We believe that when you lead with Love, Excellence is inevitable.


ChristianaCare’s comprehensive total rewards package is one of the most competitive in the region. We are proud to offer excellent benefits that reflect the organization’s commitment to being exceptional today and even better tomorrow.

At ChristianaCare, we provide access to high-quality and affordable benefits designed to meet our caregivers where they are. You can tailor your benefits to meet your needs now and adjust them as your priorities change.

Take advantage of ChristianaCare’s wide-ranging benefit offerings from supporting optimal health through medical, prescription, dental and vision coverage to valuable wellness and work/life programs, which include paid parental leave, coverage for infertility and assisted reproductive technologies, an employer-funded short-term disability program, and more.

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